An important element of its regional character is the North Pacific Coast's relative isolation from the rest of America. Less than 3 percent of the American population lives there. Populated sections of the region are separated from the other principal population centers by substantial distances of arid or mountainous terrain. Residents of the region often view this isolation as positive, a geographic buffer against the rest of the world. Economically, however, it has been a hindrance. High transportation costs inflate the price of Pacific Northwest products in distant eastern markets and discourage some manufacturers from locating in the region.
The only similarity that the North Pacific Coast has with San Francisco would be its fog. Aside from that, everything else is the opposite. Instead of the rugged mountains and the mantle of evergreens, San Francisco is composed of steep hills and tall buildings. It is very densely populated and businesses choose to locate here.
References:
http://countrystudies.us/united-states/geography-21.htm
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